Substance II-5 exhibited potent antidepressant activity in the rat tail suspension system ensure that you showed a satisfactory basic safety profile in an initial acute toxicity check in mice. Tail suspension system test (TST) outcomes of substances I-19, II-4, and II-5 and duloxetine (one dosage of 30 mg/kg), (*** 0.001). Desk 2 The result of four substances in the rat check predictive of antidepressant activity. = 14.0 Hz, -CH-), 4.46 (d, 1H, = 14.0 Hz, -CH-), 7.11C7.12 (m, 2H, ArH), 7.37C7.38 (m, 2H, ArH), 7.48 (d, 1H, = 7.6 Hz, ArH), 7.55C7.58 (m, 2H, ArH), 7.70C7.73 (m, 2H, ArH). HRMS calcd for C18H20ClN3 (M + H)+, 314.1419; present, 314.1421. = 5.4 Hz, piperazinyl-H), 3.58C3.66 (m, 4H, piperazinyl-H), 4.14 (t, 2H, = 5.4 Hz, piperazinyl-H), 4.39 (d, 1H, = 15.9 Hz, -CH-), 4.45 (d, 1H, = 15.9 Hz, -CH-), 7.07C7.11 (m, 2H, ArH), 7.35C7.38 (m, 4H, ArH), 7.45 (s, 1H, ArH), 7.56C7.61 (m, 1H, ArH), 7.73 (d, 1H, = 7.2 Hz, ArH). HRMS calcd for C18H20ClN3 (M + H)+, 314.1419; present, 314.1411. = 8.4 Hz, ArH). HRMS calcd for C18H20ClN3 (M + H)+, 314.1419; present, 314.1414. = 15.6 Hz, -CH-), 4.49 (d, 1H, = 15.6 Hz, -CH-), 7.08C7.10 (m, 2H, ArH), 7.34C7.39 (m, 4H, ArH), 7.43C7.45 (m, 2H, ArH), 7.72C7.80 (m, 1H, ArH). HRMS calcd for C18H20FN3 (M + H)+, 298.1714; present, 298.1706. = 8.4 Hz, ArH), 7.98 (d, 2H, = 8.4 Hz, ArH). HRMS CEP33779 calcd for C19H20N4 (M + H)+, 305.1761; present, 305.1760. = 15.6 Hz, -CH-), 4.44 (d, 1H, = 15.6 Hz, -CH-), 7.04C7.06 (m, 2H, ArH), 7.31C7.41 (m, 3H, ArH), 7.72C7.81 (m, 3H, ArH), 8.07 (d, 1H, = 6.9 Hz, ArH). HRMS calcd for C19H20N4 (M + H)+, 305.1761; present, 305.1758. = 5.4 Hz, = 5.1 CEP33779 Hz, piperazinyl-H), 3.59 (t, 2H, = 5.7 Hz, = 5.1 Hz, piperazinyl-H), 3.64 (t, 2H, = 5.7 Hz, piperazinyl-H), 4.12 (t, 2H, = 6.0 Hz, piperazinyl-H), 4.42 (s, 2H, -CH2-), 7.09C7.12 (m, 2H, ArH), 7.30C7.37 (m, 5H, ArH), 7.45 (d, 2H, = 8.1 Hz, ArH). HRMS calcd for C19H23N3 (M + H)+, 294.1965; present, 294.1962. = 15.6 Hz, -CH-), 4.46 Rabbit Polyclonal to MuSK (phospho-Tyr755) (d, 1H, = 15.6 Hz, -CH-), 7.05 (d, 2H, = 7.8 Hz, ArH), 7.31C7.38 (m, 3H, ArH), 7.71 (d, 1H, = 8.7 Hz, ArH), 8.35 (d, 1H, = 8.4 Hz, ArH), 8.57 (s, 1H, = 8.7 Hz, ArH). HRMS calcd for C18H19ClN4O2 (M + H)+, 359.1269; present, 359.1277. = 8.4 Hz, ArH), 7.34 (d, 2H, = 8.4 Hz, ArH), 7.67 (d, 2H, = 8.7 Hz, ArH), 8.42 (d, 2H, = 8.7 Hz, ArH). HRMS calcd for C18H19ClN4O2 (M + H)+, 359.1269; present, 359.1271. = 15.6 Hz, -CH-), 4.42 (d, 1H, = 15.6 Hz, -CH-), 7.01 (d, 2H, = 8.4 Hz, ArH), 7.33 (d, 2H, = 8.4 Hz, ArH), 7.42 (d, 1H, = 7.8 Hz, ArH), 7.55 (t, 1H, = 7.5 Hz, ArH), 7.64C7.72 (m, 2H, ArH). HRMS calcd for C18H19Cl2N3 (M + H)+, 348.1029; present, 348.1032. = 15.9 Hz, -CH-), 4.35 (d, 1H, = 15.9 Hz, -CH-), 7.03 (d, 2H, = 8.7 Hz, ArH), 7.33C7.37 (m, 3H, ArH), 7.40 (s, 1H, ArH), 7.55C7.61 (m, 1H, ArH), 7.72 (d, 1H, = 7.2 Hz, CEP33779 ArH). HRMS calcd for C18H19Cl2N3 (M + H)+, 348.1029; present, 348.1027. = 8.4 Hz, ArH), 7.35 (d, 2H, = 8.1 Hz, ArH), 7.37 (d, 2H, = 8.1 Hz, ArH), 7.63 (d, 2H, = 8.4 Hz, ArH). HRMS calcd for C18H19Cl2N3 (M + H)+, 348.1029; present, 348.1027. = 8.1 Hz, ArH), 7.31C7.37 (m, 4H, ArH), 7.42C7.47 (m, 2H, ArH). HRMS calcd for C18H19ClFN3 (M + H)+, 332.1324; present, 332.1323. = 15.6 Hz, -CH-), 4.47 (d, 1H, = 15.6 Hz, -CH-), 7.02 (d, 2H, = 8.4 Hz, ArH), 7.32C7.38 (m, 3H, ArH), 7.41C7.43 (m, 2H, ArH), 7.72C7.79 (m, 1H, ArH). HRMS calcd for C18H19ClFN3 (M + H)+, 332.1324; present, 332.1321. = 8.4 Hz, ArH),.
