Purpose To research the impact of Pro370Leu mutant myocilin on endoplasmic reticulum (ER) stress response and mitochondria function in human trabecular meshwork (HTM) cells. trabecular meshwork-inducible glucocorticoid response) can cause juvenile-onset open angle glaucoma (JOAG) [2]. More than 70 mutations in the myocilin gene contribute to the pathogenesis of approximately 3% of familial autosomal dominant […]



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